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  • Diagnosing Neonatal Encephalopathy as Hypoxic-Ischemic Encephalopathy: Interpreting Test Results in Real Time
    Hypoxic-ischemic encephalopathy (HIE), as a cause for neonatal encephalopathy, is a significant problem worldwide. Morbidity and mortality continue to be seen in association with asphyxial events before and during labor and during neonatal transition despite advances in neonatal care. Therapeutic hypothermia offers an opportunity to reduce those burdens. However, application of this therapy depends on the ability to accurately identify infants most likely to benefit. Having accurate diagnostic tests to identify such infants and being able to interpret these data quickly is crucial for the application of hypothermia. This review will discuss the major diagnostic modalities and their accuracies. This review also aims to provide a diagnostic path and method focused on probabilities and likelihoods.